Tranexamic acid in patients undergoing non-cardiac surgery

From the Population Health Research Institute (PJD, MM, DC, FKB, SNO, MKW, AL, RPW, MHM, JV, JE, IC, K. Balasubramanian, SIB, D. Stillo, TC, PSR, EPB-C., JS , WM, SY), the departments Methods, Evidence and Effects of Health Research (PJD, MM, DC, FKB, SNO, MKW, AXG, SIB, JS, GG), Medicine (PJD, MM, DC, FKB, MKW, AP , VT, JE, PLG, EPB-C., WM, GG, SY), Surgery (AL, RPW) and Anesthesia (JS, TV) and the School of Nursing (MHM), McMaster University, Hamilton, the Departments of Medicine (AXG, PSR) and Epidemiology and Biostatistics (AXG), Western University, London and the Department of Anaesthesiology and Perioperative Medicine, Queen’s University and Kingston Health Sciences Centre, Kingston (JLP), ON, the Department of Medicine, Center Hospitalier de l’Université de Montréal (ED) and the Department of Medicine, Jewish General Hospital, McGill University (TC), Montreal and the Department of Medicine, University of Saskatchewan, Saskatoon (MP) – all in Canada; the Discipline of Acute Care Medicine, University of Adelaide (TWP), and the Department of Anesthesia, Royal Adelaide Hospital (TWP), Adelaide, SA, and the Department of Anesthesia and Perioperative Medicine, Monash University (TR), and the Department of Critical Care Medicine, Melbourne Medical School, University of Melbourne (KL), Melbourne, VIC – all in Australia; the Department of Anesthesiology and Intensive Care Medicine, E. Meshalkin National Medical Research Center (VL), and the Department of Anesthesiology and Intensive Care Medicine (VL) and Department of Anesthesiology, V. Zelman Institute of Medicine and Psychology (SVA), Novosibirsk State University, Novosibirsk, Saint Petersburg State University Hospital, Saint Petersburg (SE), and V. Negovsky Reanimatology Research Institute, Department of Anesthesia and Intensive Care Medicine, First Moscow State Medical University (Sechenov University), Moscow (VVL) – all in Russia; the Divisions of Outcome Research (DIS, KR, AT) and General Anesthesia (KR, AT) and Institute of Anesthesiology (DIS, KR, AT), Cleveland Clinic, Cleveland; Chinese University of Hong Kong, Shatin, China (MTVC, WKKW); Cochrane Iberoamerican Center, Public Health and Clinical Epidemiology Service, Institut d’Investigació Biomèdica Sant Pau, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (MJM-Z.), Department of Anaesthesiology and Intensive Care Medicine, Vall d’Hebron Hospital , Universitat Autònoma de Barcelona (MN), and the Department of Anesthesia, University Hospital Santa Creu i Sant Pau (PP), Barcelona, ​​​​and the Department of Trauma and Orthopedic Surgery, Hospital Clínico Universitario de Valladolid, Valladolid (HJA) – all in Spain; the Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia (C.-YW); St. John’s Medical College, Bangalore (DX, MR) and the Department of Gastrointestinal Surgery, Surat Institute of Digestive Sciences Hospital and Research Center, Surat (K. Bhatt) – both in India; the Department of Anaesthesiology and Intensive Care Medicine, IRCCS San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan (GL); the Department of Orthopedics and Trauma Surgery, Deventer Ziekenhuis, Deventer, The Netherlands (YVK); Jagiellonian University Medical School, Center for Intensive Care and Perioperative Medicine, Kraków, Poland (WS); Center Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels (D. Schmartz); the Department of Anaesthesiology, Auckland City Hospital and the School of Health Sciences, University of Auckland, Auckland, New Zealand (TGS); the Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany (MW); the Department of Anesthesia and Intensive Care Medicine, Copenhagen University Hospital – Bispebjerg and Frederiksberg, and the Department of Clinical Medicine, University of Copenhagen, Copenhagen (CSM); Shifa International Hospital, Islamabad, Pakistan (MA); Departamento de Epidemiología y Estudios en Salud, Universidad de Los Andes, and Servicio de Anestesiología, Clínica Santa María, Santiago, Chile (DT); the Department of Anesthesia, General Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna (EF); Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, National Institute for Health Technology Assessment and Hospital Moinhos de Vento, Porto Alegre, Brazil (CAP); and the Department of Anesthesia, Paris Saint Joseph Hospital, University of Paris, Paris (PA).

dr Devereaux can be contacted at or at the David Braley Research Institute, Hamilton General Hospital, 237 Barton St. East, Hamilton, ON L8L 2X2, Canada.

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